Conversion of pyruvate into ketone bodies in rat hepatocyte suspensions
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منابع مشابه
Lipogenesis from ketone bodies in rat brain. Evidence for conversion of acetoacetate into acetyl-coenzyme A in the cytosol.
The metabolism of acetoacetate via a proposed cytosolic pathway in brain of 1-week-old rats was investigated. (-)-Hydroxycitrate, an inhibitor of ATP citrate lyase, markedly inhibited the incorporation of carbon from labelled glucose and 3-hydroxybutyrate into cerebral lipids, but had no effect on the incorporation of labelled acetate and acetoacetate into brain lipids. Similarly, n-butylmalona...
متن کاملDepolarizing actions of GABA in immature neurons depend neither on ketone bodies nor on pyruvate.
GABA depolarizes immature neurons because of a high [Cl(-)](i) and orchestrates giant depolarizing potential (GDP) generation. Zilberter and coworkers (Rheims et al., 2009; Holmgren et al., 2010) showed recently that the ketone body metabolite DL-3-hydroxybutyrate (DL-BHB) (4 mM), lactate (4 mM), or pyruvate (5 mM) shifted GABA actions to hyperpolarizing, suggesting that the depolarizing effect...
متن کاملThe determination of ketone bodies.
Roche, J., Michel, R. & Jouan, P. (1957). Ciba Foundation Colloq. Endocrin. 10, 168. Rosenberg, I. N. (1951). J. clin. Inve8t. 30, 1. Schultz, A. L., Sandhaus, S., Demorest, H. L. & Zieve, L. (1954). J. clin. Endrocrin. 14, 1062. Sprott, W. E. & Maclagan, N. F. (1955). Biochem. J. 59,288. Taurog, A., Briggs, F. N. & Chaikoff, I. L. (1952). J. biol. Chem. 194, 655. Taurog, A., Chaikoff, I. L. & ...
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A combination of isotope-dilution and arteriovenous-difference techniques was used to determine the significance of ketones to energy homoeostasis in fasted pregnant ewes. 2. There was incomplete interconversion of D(-) 3-hydroxybutyrate (3HB) and acetoacetate (AcAc) and therefore neither entry rate nor oxidation of total ketone bodies could be estimated by assuming circulating ketone bodies re...
متن کاملKetone bodies, potential therapeutic uses.
Ketosis, meaning elevation of D-beta-hydroxybutyrate (R-3hydroxybutyrate) and acetoacetate, has been central to starving man's survival by providing nonglucose substrate to his evolutionarily hypertrophied brain, sparing muscle from destruction for glucose synthesis. Surprisingly, D-beta-hydroxybutyrate (abbreviated "betaOHB") may also provide a more efficient source of energy for brain per uni...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1985
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2310565